Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice

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Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice.

OBJECTIVE To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. METHODS The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable E...

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Evaluation of antitumor activity of Manilkara zapota leaves against Ehrlich ascites carcinoma in mice

This study has been designed to explore in vivo the antitumuor activity of the ethyl acetate extract of leaves of Manilkara zapota (EALM) against Ehrlich ascites carcinoma (EAC). The antitumour activity of EALM against EAC was evaluated at doses of 50, 100 and 200 mg kg–1 day–1. Intraperitoneal treatment with EALM (at 100 and 200 mg kg–1 day–1) showed a significant increase in survival time and...

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Antitumor Activity and In Vivo Antioxidant Status of Mucuna Pruriens (Fabaceae) Seeds against Ehrlich Ascites Carcinoma in Swiss Albino Mice

The aim of the present study is to evaluate the antitumor effect and antioxidant role of Mucuna pruriens (Family: Fabaceae) against EAC bearing Swiss albino mice. The effect of methanol extract of Mucuna pruriens (MEMP) on tumor growth and hosts survival time was studied by the following parameters: tu-mor volume, packed cell volume, viable and non-viable cell count and life span of the host. M...

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In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice

OBJECTIVE Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities. METHODS Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological pa...

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Anticancer screening of Gomphrena globosa against ehrlich ascites carcinoma in swiss albino mice

Based on the ethno pharmacological evidence, the present study was performed to investigate the anticancer activity of chloroform extract of aerial parts of Gomphrena globosa against Ehrlich Ascites Carcinoma (EAC) induced solid tumor. Acute toxicity study shows that, the extract was non-toxic up to 2000 mg / kg body wt. Administration of 200 or 400 mg / kg p.o. in mice, caused significant redu...

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ژورنال

عنوان ژورنال: Asian Pacific Journal of Tropical Biomedicine

سال: 2011

ISSN: 2221-1691

DOI: 10.1016/s2221-1691(11)60098-1